Kumita S, Cho K, Mizumura S, Kjima T, Ishihara M, Toba M, Inoue K, Kumazaki T, Sano J, Tada Y, Tetsuou Y, Sakai S, Kusama Y, Munakata K
Department of Radiology, Nippon Medical School.
Kaku Igaku. 1997 Apr;34(4):237-42.
Non-invasive assessment of ischemic heart disease requires information of both LV function and myocardial perfusion. Recently, ECG-gated myocardial SPECT with technetium-labeled radiopharma-ceuticals can provide both of them. Gated myocardial SPECT were performed in thirty-three patients with cardiac disease using a two-headed rotating gamma camera system (ADAC; VERTEX), 30-60 minutes after resting injection of 555-740 MBq of 99mTc-Tetrofosmin. Then, the SPECT data were used to determine the LV epi- and endocardial surface, and LV volume for measurement of LVEF was calculated automatically. This entire computational process required only 210 seconds per 16 frame study. Interobserver agreement of EF values obtained from gated SPECT was excellent (r = 0.996, n = 10, p < 0.01). LVEFs obtained from gated SPECT showed good correlation to those calculated from radionuclide ventriculography (MUGA) (r = 0.91, p < 0.01). In conclusion, this automatic method using gated myocardial SPECT data was considered to be useful for assessment of LV function with reproducibility.
缺血性心脏病的无创评估需要左心室功能和心肌灌注两方面的信息。近来，采用锝标记放射性药物的心电图门控心肌单光子发射计算机断层扫描（SPECT）能够提供这两方面的信息。对33例心脏病患者，在静脉注射555 - 740MBq的99mTc - 替曲膦后30 - 60分钟，使用双头旋转γ相机系统（ADAC；VERTEX）进行门控心肌SPECT检查。然后，利用SPECT数据确定左心室心外膜和心内膜表面，并自动计算用于测量左心室射血分数（LVEF）的左心室容积。每16帧图像的整个计算过程仅需210秒。门控SPECT获得的射血分数值的观察者间一致性极佳（r = 0.996，n = 10，p < 0.01）。门控SPECT获得的LVEF与放射性核素心室造影（MUGA）计算得到的LVEF具有良好的相关性（r = 0.91，p < 0.01）。总之，这种使用门控心肌SPECT数据的自动方法被认为可用于具有可重复性的左心室功能评估。
