Rumsey J M, Horwitz B, Donohue B C, Nace K, Maisog J M, Andreason P
Child Psychiatry Branch, National Institute of Mental Health (NIMH), Bethesda, MD 20892, USA.
Brain. 1997 May;120 ( Pt 5):739-59. doi: 10.1093/brain/120.5.739.
Pronunciation (of irregular/inconsistent words and of pseudowords) and lexical decision-making tasks were used with 15O PET to examine the neural correlates of phonological and orthographic processing in 14 healthy right-handed men (aged 18-40 years). Relative to a visual-fixation control task, all four experimental tasks elicited a left-lateralized stream of activation involving the lingual and fusiform gyri, perirolandic cortex, thalamus and anterior cingulate. Both pronunciation tasks activated the left superior temporal gyrus, with significantly greater activation seen there during phonological (pseudoword) than during orthographic (real word) pronunciation. The left inferior frontal cortex was activated by both decision-making tasks; more intense and widespread activation was seen there during phonological, than during orthographic, decision making, with the activation during phonological decision-making extending into the left insula. Correlations of reference voxels in the left superior temporal gyrus and left inferior frontal region with the rest of the brain were highly similar for the phonological and orthographic versions of each task type. These results are consistent with connectionist models of reading, which hypothesize that both real words and pseudowords are processed within a common neural network.
使用发音（针对不规则/不一致的单词和假词）和词汇判断任务，结合15O正电子发射断层扫描（PET），对14名健康右利手男性（年龄在18 - 40岁之间）的语音和正字法加工的神经关联进行研究。相对于视觉注视控制任务，所有四项实验任务均引发了左侧化的激活流，涉及舌回、梭状回、中央旁小叶、丘脑和前扣带回。两项发音任务均激活了左侧颞上回，在语音（假词）发音过程中该区域的激活明显大于正字法（真实单词）发音过程。两项判断任务均激活了左侧额下回；在语音判断过程中，该区域的激活比正字法判断过程更强烈、更广泛，且语音判断过程中的激活延伸至左侧脑岛。对于每种任务类型的语音和正字法版本，左侧颞上回和左侧额下区域的参考体素与大脑其他部分的相关性高度相似。这些结果与阅读的联结主义模型一致，该模型假设真实单词和假词均在一个共同的神经网络中进行加工。
