家族性混合性高脂血症是一种脂肪组织的遗传性疾病吗？
Is familial combined hyperlipidaemia a genetic disorder of adipose tissue?
作者信息
Arner P
机构信息
Karolinska Institute, Department of Medicine, Huddinge Hospital, Sweden.
出版信息
Curr Opin Lipidol. 1997 Apr;8(2):89-94. doi: 10.1097/00041433-199704000-00006.
Abstract
Familial combined hyperlipidaemia is a common cause of coronary heart disease. Its aetiology is heterogeneous. The genetic and metabolic basis of the disorder has not yet been defined. This review discusses the putative role of adipose tissue in the pathogenesis of familial combined hyperlipidaemia. It is possible that mutations in genes regulating the turnover of lipids in fat cells are involved in the aetiology.
摘要
家族性混合性高脂血症是冠心病的常见病因。其病因具有异质性。该疾病的遗传和代谢基础尚未明确。本综述讨论了脂肪组织在家族性混合性高脂血症发病机制中的假定作用。调节脂肪细胞脂质周转的基因突变可能参与了其病因。
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