Fassina G, Osculati A, Hill H M
Institute of Legal Medicine, University of Pavia, Italy.
Nihon Hoigaku Zasshi. 1997 Apr;51(2):77-82.
The brain of 34 subjects who died after prolonged resuscitation (more than 20 days) were studied in order to evaluate the possibility of discriminating original cerebral injuries from changes caused by prolonged resuscitation. We focused our attention on the astrocytic reaction and its relationship to the associated lesions. Twelve of the 34 cases showed astrocytosis picture. Of these 5 were anisomorphic and 7 isomorphic. From the analysis of the various morphological findings, taking into account an individual's clinical history, we can conclude that isomorphic astrocytosis is a typical morphological reaction related to resuscitation duration and it is the result of a slow, gradual neuronal degeneration induced by chronic hypoxia. Anisomorphic astrocytosis, on the other hand, can be an indicator of acute and focal cerebral lesion.
为了评估区分原发性脑损伤与长时间复苏所造成变化的可能性，我们对34例经过长时间复苏（超过20天）后死亡的受试者的大脑进行了研究。我们将注意力集中在星形胶质细胞反应及其与相关病变的关系上。34例病例中有12例呈现星形细胞增多的表现。其中5例为异形性星形细胞增多，7例为同形性星形细胞增多。通过对各种形态学发现进行分析，并考虑个体的临床病史，我们可以得出结论，同形性星形细胞增多是与复苏持续时间相关的典型形态学反应，它是慢性缺氧诱导的缓慢、渐进性神经元变性的结果。另一方面，异形性星形细胞增多可能是急性局灶性脑损伤的一个指标。
