Chevarley F, White E
Division of Health Interview Survey, National Center for Health Statistics, Hyattsville, Md 20782, USA.
Am J Public Health. 1997 May;87(5):775-81. doi: 10.2105/ajph.87.5.775.
Time trends in breast cancer mortality were analyzed from 1970 to 1992 among White and Black US women aged 25 and over.
Mortality data from the National Center for Health Statistics were summarized within three periods 1970 to 1979, 1980 to 1988, and 1989 to 1992. The annual change was calculated as the average yearly percentage of change based on the logistic model.
For White women of all ages, breast cancer mortality decreased by 1.6% (95% confidence interval = -2.0%, -1.1%) per year on average during 1989 to 1992, in contrast to the flat mortality rates observed during the 1970s and a 0.5% average annual increase during 1980 to 1988. The decline was observed for White women under age 60, among whom breast cancer mortality had been decreasing, and for White women aged 60 to 79, among whom breast cancer mortality had been increasing, but it was not observed among Black women.
The long-awaited decline in US breast cancer mortality has finally appeared, although only among White women. The possible contributions are changes in inherent risk of disease, changes in treatment effectiveness, and increased use of screening mammography.
分析1970年至1992年间25岁及以上美国白人和黑人女性乳腺癌死亡率的时间趋势。
美国国家卫生统计中心的死亡率数据在1970年至1979年、1980年至1988年和1989年至1992年三个时间段内进行汇总。年度变化以基于逻辑模型的平均年变化百分比来计算。
对于所有年龄段的白人女性,1989年至1992年期间乳腺癌死亡率平均每年下降1.6%(95%置信区间 = -2.0%,-1.1%),这与20世纪70年代观察到的死亡率持平以及1980年至1988年期间平均每年0.5%的上升形成对比。60岁以下的白人女性中出现了下降趋势,她们的乳腺癌死亡率一直在下降;60至79岁的白人女性中也出现了下降趋势,她们的乳腺癌死亡率此前一直在上升,但黑人女性中未观察到这种下降。
美国乳腺癌死亡率期待已久的下降终于出现了,不过仅出现在白人女性中。可能的原因包括疾病固有风险的变化、治疗效果的变化以及乳腺钼靶筛查的使用增加。