Said G, Bathien N
Rev Neurol (Paris). 1977 Mar;133(3):191-8.
A case of rhythmic myoclonus of the quadriceps related to involvement of the crural nerve by a schwann-cell sarcoma of the thigh is reported. The rhythm of involuntary contractions varies between 35 and 300 per minute. The myoclonic jerks occur rhythmically in the quadriceps only during full extension of the knee. The jerks are inhibited during lengthening of the quadriceps by active or passive flexion of the knee. Clonazepam is very effective in controlling the myoclonus. It is suggested that the myoclonus is the consequence of a response of alpha-motoneurons of the spinal cord to the excitation of Ia fibers of the crural nerve by the tumor. This activation appears to be enhanced by descending excitation pathway and inhibited by activation of Golgi tendon organs of the quadriceps.
报告了1例与大腿神经鞘细胞肉瘤累及股神经相关的股四头肌节律性肌阵挛。非自主收缩的节律在每分钟35次至300次之间变化。肌阵挛性抽搐仅在膝关节完全伸展时于股四头肌有节律地发生。当通过主动或被动屈膝使股四头肌延长时，抽搐受到抑制。氯硝西泮在控制肌阵挛方面非常有效。有人认为，肌阵挛是脊髓α运动神经元对肿瘤刺激股神经Ia纤维所产生反应的结果。这种激活似乎因下行兴奋通路而增强，并因股四头肌高尔基腱器官的激活而受到抑制。
