Blatrix C, Thebault J, Steinbuch M
Rev Fr Transfus Immunohematol. 1977 Sep;20(3):419-26. doi: 10.1016/s0338-4535(77)80076-7.
A new immunoglobulin preparation, called IgGAM, has been obtained from fraction III. Fraction III obtained during large scale fractionation is used as starting material and caprylic acid for the precipitation of most proteins other than the immunoglobulins present in fraction III; the immunoglobulin concentrate is finally obtained by ethanol precipitation of the supernatant. The IgGAM preparation contains IgG,IgA and IgM in various proportions according to the modifications of the initial technique, and we can obtain fractions more specially enriched in IgA or in IgM. The clinical results obtained with IgGAM preparation are summarized; different types of antibody deficiency syndromes have been successfully treated. It can be injected once à week IM, at a dose of 0.5 ml/kg. No side effects, nor appearance of anti IgA antibodies have been observed.
一种名为IgGAM的新型免疫球蛋白制剂已从Ⅲ组分中获得。大规模分级分离过程中得到的Ⅲ组分用作起始原料，用辛酸沉淀Ⅲ组分中除免疫球蛋白以外的大多数蛋白质；最后通过对上清液进行乙醇沉淀获得免疫球蛋白浓缩物。根据初始技术的改进，IgGAM制剂含有不同比例的IgG、IgA和IgM，我们可以获得更特别富含IgA或IgM的组分。总结了使用IgGAM制剂获得的临床结果；不同类型的抗体缺乏综合征已得到成功治疗。它可以每周一次肌肉注射，剂量为0.5 ml/kg。未观察到副作用，也未出现抗IgA抗体。
