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[使用富含IgA和IgM的新型免疫球蛋白制剂(IgGAM)]

[The use of new immunoglobulin preparation, enriched in IgA and IgM (IgGAM)].

作者信息

Blatrix C, Israël J, Reinert P, Griscelli C, Steinbuch M

出版信息

Nouv Presse Med. 1976 May 1;5(18):1193-5.

PMID:58407
Abstract

The clinical results obtained with fraction IgGAM are reported. Different types of antibody deficiency syndromes have successfully been treated : 8 cases of Bruton-type agammaglobulinemia. In one of these case a tenacious Pseudomonas infection cleared off during the treatment. Two cases of non sex-linked familial agammaglobulinemia. Three cases of isolated IgM deficiency. Five cases of isolated IgA deficiency. Five cases with Soothill type IgA deficiency associated with high IgE levels. Five cases of septicemia of the new-born. Three cases with acquired agammaglobulinemia and in the premature infant (5 cases). No side-effects nor appearance of anti-IgA antibodies have been observed.

摘要

报道了使用分段IgGAM获得的临床结果。不同类型的抗体缺乏综合征已成功得到治疗:8例布鲁顿型无丙种球蛋白血症。其中1例在治疗期间顽固的铜绿假单胞菌感染得以清除。2例非性连锁家族性无丙种球蛋白血症。3例孤立性IgM缺乏。5例孤立性IgA缺乏。5例伴有高IgE水平的苏西尔型IgA缺乏。5例新生儿败血症。3例获得性无丙种球蛋白血症以及早产儿(5例)。未观察到副作用或抗IgA抗体的出现。

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