Complement-dependence of platelet serotonin release test in polytransfused patients.

The research of platelet isoantibodies in patients with Cooley's anaemia was performed by simultaneous determination of the platelet-complement fixation test, platelet factor 3 availability assay and 14C-serotonin release test. In 93% of the examined patients we obtained positive results with the 5HT-release test, which appeared to be a complement-dependent reaction in most of the sera-containing isoantibodies, different from sera of patients affected by autoimmune thrombocytopenia.