Onishi J C, Milligan J A, Basilio A, Bergstrom J, Curotto J, Huang L, Meinz M, Nallin-Omstead M, Pelaez F, Rew D, Salvatore M, Thompson J, Vicente F, Kurtz M B
Merck Research Laboratories, Rahway, NJ 07065-0900, USA.
J Antibiot (Tokyo). 1997 Apr;50(4):334-8. doi: 10.7164/antibiotics.50.334.
A family of aminoacyl alkyl citrate compounds called viridiofungins, are novel squalene synthase inhibitors. The compounds have broad spectrum fungicidal activity but lack antibacterial activity. Although the compounds inhibit squalene synthase, the first committed step in ergosterol biosynthesis, results presented in this paper show that inhibition of fungal growth is not related to inhibition of ergosterol synthesis.
一类名为绿僵菌素的氨酰基烷基柠檬酸酯化合物是新型的角鲨烯合酶抑制剂。这些化合物具有广谱杀菌活性，但缺乏抗菌活性。尽管这些化合物抑制角鲨烯合酶（麦角甾醇生物合成中的首个关键步骤），但本文给出的结果表明，抑制真菌生长与抑制麦角甾醇合成无关。
