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5-羟色胺1D和5-羟色胺2B受体介导人类小肠平滑肌收缩。

5-HT1D and 5-HT2B receptors mediate contraction of smooth muscle in human small intestine.

作者信息

Borman R A, Burleigh D E

机构信息

Department of Pharmacology, Queen Mary & Westfield College, University of London, United Kingdom.

出版信息

Ann N Y Acad Sci. 1997 May 30;812:222-3. doi: 10.1111/j.1749-6632.1997.tb48182.x.

DOI:10.1111/j.1749-6632.1997.tb48182.x
PMID:9186750
Abstract

In conclusion, 5-HT has been shown to contract both circular and longitudinal muscle layers of human terminal ileum. By the use of selective antagonists, the receptors mediating these actions have been identified. In the circular muscle of human small intestine, 5-HT-induced contraction is mediated via a receptor of the 5-HT1D sub-type, whereas a receptor of the 5-HT2B sub-type mediates the contractile response to 5-HT of longitudinal muscle layers.

摘要

总之，已证实5-羟色胺（5-HT）可使人类回肠末端的环形肌层和纵形肌层收缩。通过使用选择性拮抗剂，介导这些作用的受体已得到确认。在人类小肠环形肌中，5-HT诱导的收缩是通过5-HT1D亚型受体介导的，而5-HT2B亚型受体介导纵形肌层对5-HT的收缩反应。

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