Nakano S, Imamura S, Tokunaga K, Tsuji S, Hashimoto I
Department of Internal Medicine, Kumamoto Rosai Hospital.
Intern Med. 1997 Apr;36(4):270-5. doi: 10.2169/internalmedicine.36.270.
P300, somatosensory evoked potential (SEP) and brainstem auditory evoked potential (BAEP) are widely used neurophysiological methods for objectively evaluating cognitive, somatosensory and brainstem auditory functions. We studied the P300, SEP and BAEP in 17 patients with chronic respiratory insufficiency (PaO2:58.2 +/- 7.0 mmHg; mean +/- SD) and 15 age-matched healthy subjects (PaO2: 84.4 +/- 11.3 mmHg). The latency and amplitude of P300, the N9 latency, N9-N13 and N13-N20 interpeak latencies (IPL) in SEP, wave I latency and I-V IPL in BAEP were compared between the patients and controls. The P300 latency, N9-N13 and N13-N20 IPLs in SEP in the patients were significantly prolonged compared to the controls. In contrast, the amplitude of P300, N9 latency in SEP, wave I latency and I-V IPL in BAEP were not significantly different between the patients and controls. These results suggest that chronic respiratory insufficiency influences the cognitive and somatosensory functions, and indicate that there is a selective vulnerability of evoked potentials to this condition.
P300、体感诱发电位（SEP）和脑干听觉诱发电位（BAEP）是广泛用于客观评估认知、体感和脑干听觉功能的神经生理学方法。我们对17例慢性呼吸功能不全患者（动脉血氧分压：58.2±7.0 mmHg；平均值±标准差）和15名年龄匹配的健康受试者（动脉血氧分压：84.4±11.3 mmHg）进行了P300、SEP和BAEP研究。比较了患者与对照组之间P300的潜伏期和波幅、SEP中的N9潜伏期、N9-N13和N13-N20峰间潜伏期（IPL）、BAEP中的I波潜伏期和I-V IPL。与对照组相比，患者组的P300潜伏期、SEP中的N9-N13和N13-N20 IPL显著延长。相比之下，患者与对照组之间P300的波幅、SEP中的N9潜伏期、BAEP中的I波潜伏期和I-V IPL无显著差异。这些结果表明慢性呼吸功能不全会影响认知和体感功能，并表明诱发电位对这种情况存在选择性易损性。
