Sanders H, Graham S D
Emory University School of Medicine, Atlanta, Georgia 30322, USA.
Urology. 1997 Jun;49(6):894-7. doi: 10.1016/s0090-4295(97)00090-3.
To compare four assays-the Abbott IMx, the Tosoh, the Chiron ACS PSA, and the Chiron ACS PSA2-in their ability to detect prostate-specific antigen (PSA) after radical prostatectomy.
Serum samples were drawn on all men who had had a previous radical prostatectomy and who were seen in the urology clinic in March 1995. The results of each assay were compared using linear regression.
Twenty-two patients had an undetectable PSA by the IMx assay. The PSA was over the residual cancer detection limit (RCDL) of the Tosoh assay in 5 of these patients. The PSA was over the RCDL of the ACS PSA assay in 15 of these patients and over the RCDL of the PSA2 assay in 2 patients. There were no patients whose PSA was less than the RCDL of the ACS PSA assay who had a measurable PSA level by any of the other assays.
There is a difference among PSA assays in their ability to detect low levels of PSA after radical prostatectomy. The ACS PSA assay is the most sensitive, and the IMx assay is the least sensitive.
比较四种检测方法——雅培IMx、东曹、凯龙ACS PSA和凯龙ACS PSA2——在根治性前列腺切除术后检测前列腺特异性抗原（PSA）的能力。
采集所有曾接受过根治性前列腺切除术且于1995年3月在泌尿外科门诊就诊的男性的血清样本。使用线性回归比较每种检测方法的结果。
22例患者通过IMx检测法检测不到PSA。其中5例患者的PSA超过了东曹检测法的残留癌检测限（RCDL）。这些患者中有15例的PSA超过了ACS PSA检测法的RCDL，2例超过了PSA2检测法的RCDL。没有患者的PSA低于ACS PSA检测法的RCDL却能通过其他任何检测法检测到可测量的PSA水平。
PSA检测方法在根治性前列腺切除术后检测低水平PSA的能力上存在差异。ACS PSA检测法最敏感，IMx检测法最不敏感。
