Prestigiacomo A F, Stamey T A
Department of Urology, Stanford University School of Medicine, California 94305-5118.
J Urol. 1994 Nov;152(5 Pt 1):1515-9. doi: 10.1016/s0022-5347(17)32459-x.
The Yang Pros-Check, Abbott IMx, Tosoh AIA-PACK PA and Nichols Institute reference laboratory prostate specific antigen (PSA) assays were compared in 30 patients (138 sera) known to have no residual prostate cells. The mean + 3 standard deviations of these sera was used to define a level of PSA that would indicate residual cancer. This residual cancer detection limit for each of the 4 assays is 0.06, 0.01, 0.07 and 0.05 ng./ml., respectively, but the 0.01 level for the IMx assay is an artifact caused by setting the zero calibrator too high. All 4 assays were then used to compare the number of days from radical prostatectomy to the detection of residual cancer in 23 cases (211 sera) that ultimately failed radical prostatectomy. The Yang, Tosoh and Nichols Institute assays were all similar, with an average of 569 to 589 days. The Abbott IMx assay was relatively insensitive in detecting the first appearance of PSA after radical prostatectomy (average 821 days) and it showed the earliest detection among the 4 assays in only 1 of 23 patients.
在30名已知无残留前列腺细胞的患者（138份血清）中，对杨Pros-Check、雅培IMx、东曹AIA-PACK PA和尼科尔斯研究所参考实验室的前列腺特异性抗原（PSA）检测方法进行了比较。这些血清的均值加3个标准差被用于定义一个可提示残留癌的PSA水平。这4种检测方法各自的残留癌检测限分别为0.06、0.01、0.07和0.05纳克/毫升，但IMx检测法的0.01水平是由于零校准物设定过高导致的假象。随后，使用所有4种检测方法比较了23例（211份血清）最终根治性前列腺切除术失败的患者从根治性前列腺切除到检测到残留癌的天数。杨、东曹和尼科尔斯研究所的检测方法都相似，平均为569至589天。雅培IMx检测法在检测根治性前列腺切除术后PSA的首次出现方面相对不敏感（平均821天），在23例患者中只有1例其检测时间在4种检测方法中最早。
