Ferguson J D, Galligan D T, Cortese V
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, New Bolton Center, Kennett Square 19348, USA.
J Am Vet Med Assoc. 1997 Jun 15;210(12):1779-83.
To assess the effect of vaccination against bovine respiratory syncytial virus on milk production, reproductive performance, and health in lactating dairy cows.
Prospective randomized block design.
385 Holstein dairy cows and heifers.
Cows were grouped by lactation number, season of calving, and previous mature equivalent 305-day milk production (where appropriate). Prior to parturition, cows and heifers were randomly assigned to be vaccinated i.m. against infectious bovine rhinotracheitis, bovine viral diarrhea, and parainfluenza 3 viruses by use of a three-way vaccine, or to be vaccinated against those viruses as well as bovine respiratory syncytial virus, using a four-way vaccine. Milk production was measured daily through 305 days of lactation. Reproductive and medical records were reviewed to obtain insemination dates and record medical problems of cows in each vaccine treatment group.
Compared with the three-way vaccine, administration of the four-way vaccine was associated with higher milk production (1.39 kg [3.06 lb] more milk/d) in first-parity cows during the first 21 weeks of lactation. Vaccination did not have any effect on milk production after the first 21 weeks of lactation in cows of any parity. Conception rates at first insemination were higher for four-way vaccinated first-parity cows than for three-way vaccinated first-parity cows (54.6 vs 32.7%). Compared with second-parity cows that received the three-way vaccine, first insemination conception rate was improved for second-parity cows vaccinated with the four-way vaccine (28.9 vs 47.8%, respectively). In cows of third or greater parity, first insemination conception rate was not different between the 2 vaccine treatment groups.
Vaccination of heifers against bovine respiratory syncytial virus prior to partrition may increase milk production and first insemination conception rates.
评估接种牛呼吸道合胞病毒疫苗对泌乳奶牛产奶量、繁殖性能和健康状况的影响。
前瞻性随机区组设计。
385头荷斯坦奶牛和小母牛。
根据泌乳次数、产犊季节和之前的305天成熟当量产奶量（如适用）对奶牛进行分组。在分娩前，奶牛和小母牛被随机分配接受肌肉注射，使用三联疫苗接种传染性牛鼻气管炎、牛病毒性腹泻和副流感3型病毒，或使用四联疫苗接种这些病毒以及牛呼吸道合胞病毒。在整个305天的泌乳期内每天测量产奶量。查阅繁殖和医疗记录以获取授精日期，并记录每个疫苗治疗组奶牛的医疗问题。
与三联疫苗相比，在泌乳的前21周，初产奶牛接种四联疫苗与更高的产奶量相关（每天多产奶1.39千克[3.06磅]）。在任何胎次的奶牛中，泌乳21周后接种疫苗对产奶量没有任何影响。四联疫苗接种的初产奶牛首次授精的受胎率高于三联疫苗接种的初产奶牛（分别为54.6%和32.7%）。与接受三联疫苗的经产奶牛相比，接种四联疫苗的经产奶牛首次授精受胎率有所提高（分别为28.9%和47.8%）。在第三胎及以上胎次的奶牛中，两个疫苗治疗组的首次授精受胎率没有差异。
在分娩前给小母牛接种牛呼吸道合胞病毒疫苗可能会提高产奶量和首次授精受胎率。
