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妊娠期嗜铬细胞瘤的麻醉

Anaesthesia for phaeochromocytoma in pregnancy.

作者信息

Hamilton A, Sirrs S, Schmidt N, Onrot J

机构信息

University of British Columbia Department of Anaesthesia, St Pauls' Hospital, Vancouver, Canada.

出版信息

Can J Anaesth. 1997 Jun;44(6):654-7. doi: 10.1007/BF03015450.

Abstract

PURPOSE

Phaeochromocytoma in pregnancy is a rare occurrence. Details of the anaesthetic are even more rarely reported. Our purpose is to describe our management with reference to previous reports.

CLINICAL FEATURES

A 31-yr-old woman underwent resection of a phaeochromocytoma at seven weeks gestation. Preoperative preparation included 2 mg prazosin p.o. bid and 40 mg propranolol p.o. bid. A balanced anaesthetic technique including 5 mg midazolam, 1500 micrograms alfentanil, 35 micrograms sufentanil, nitrous oxide and isoflurane was used. Blood pressure was controlled with 3.4 g magnesium and 2437 micrograms nitroglycerin. There were no episodes of hypertension intraoperatively. The patient made an uneventful recovery and delivered a normal baby at 37 wk gestation by caesarean section.

CONCLUSION

Anaesthesia for resection of a phaeochromocytoma in early pregnancy can be successfully managed with preoperative alpha and beta sympathetic blockade and a balanced anaesthetic technique using magnesium as the main intraoperative hypotensive agent.

摘要

目的

妊娠期嗜铬细胞瘤较为罕见。关于其麻醉细节的报道更是少之又少。我们的目的是参照既往报道描述我们的处理方法。

临床特征

一名31岁女性在妊娠7周时接受了嗜铬细胞瘤切除术。术前准备包括口服哌唑嗪2毫克,每日两次,以及口服普萘洛尔40毫克,每日两次。采用了包括5毫克咪达唑仑、1500微克阿芬太尼、35微克舒芬太尼、氧化亚氮和异氟烷的平衡麻醉技术。使用3.4克镁和2437微克硝酸甘油控制血压。术中未发生高血压发作。患者恢复顺利,并在妊娠37周时剖宫产分娩了一名正常婴儿。

结论

妊娠早期嗜铬细胞瘤切除术的麻醉可通过术前α和β交感神经阻滞以及以镁作为主要术中降压药物的平衡麻醉技术成功实施。

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