Buchanan N, van der Walt L A
S Afr Med J. 1977 Sep 17;52(13):522-5.
The protein binding of 6 antituberculous drugs--ethambutol, ethionamide, isoniazid, para-aminosalicylic acid, rifampicin and streptomycin--to normal and kwashiorkor serum has been investigated. The binding of these drugs was mildly decreased in kwashiorkor serum, but not to such an extent as to be of therapeutic importance, except for streptomycin and possibly para-aminosalicylic acid (PAS). With streptomycin there was a 15% increase in the free component in kwashiorkor serum, while with PAS there was a 12% increase in the free component. Of interest is the observation that rifampicin is predominantly bound to the gamma-globulin fraction, both in normal and in kwashiorkor serum. Secondary binding, predominantly to the alpha 1-, alpha 2-and gamma-globulin fractions, was seen quite commonly in kwashiorkor serum in association with diminished albumin binding.
已对六种抗结核药物——乙胺丁醇、乙硫异烟胺、异烟肼、对氨基水杨酸、利福平和链霉素——与正常血清和夸休可尔症血清的蛋白结合情况进行了研究。在夸休可尔症血清中，这些药物的结合略有减少，但除链霉素以及可能的对氨基水杨酸（PAS）外，减少程度未达到具有治疗重要性的水平。对于链霉素，夸休可尔症血清中的游离成分增加了15%，而对于PAS，游离成分增加了12%。有趣的是，观察发现利福平在正常血清和夸休可尔症血清中均主要与γ-球蛋白部分结合。在夸休可尔症血清中，由于白蛋白结合减少，常可见到主要与α1-、α2-和γ-球蛋白部分结合的二级结合。
