Reichle F A, Rao N S, Reichle R M, Chang K H
Surgery. 1977 Nov;82(5):738-49.
To determine the influence on postoperative hepatic mass, body weight, ammonia clearance, hepatic urea cycle enzyme activity, and hepatic protein metabolism, 59 dogs were divided into six experimental groups: sham operation end-to-side portacaval shunt, mesocaval shunt with subsequent end-to-side portacaval shunt, distal splenorenal shunt, caval left portal shunt, and portal venous seqregation with juglar vein interposition. Compared to total shunt, selective diversion of portal blood from the liver produces less postshunt liver atrophy, less body weight loss, improved maintenance of urea cycle enzyme activity, improved ammonia tolerance, and less decrease in hepatic deoxyribonucleic acid (DNA), ribonucleic acid (RNA), and protein content. Segregation of left from right hepatic lobes, in relationship to portal or systemic venous hepatic perfusion or in relationship to gastroduodenopancreaticosplenic or intestinal portal venous drainage, caused little change in enzyme or protein metabolism in respective hepatic lobes.
为了确定对术后肝脏质量、体重、氨清除率、肝脏尿素循环酶活性和肝脏蛋白质代谢的影响，将59只狗分为六个实验组：假手术、端侧门腔分流术、肠系膜上腔静脉分流术并随后进行端侧门腔分流术、远端脾肾分流术、腔静脉左门静脉分流术以及门静脉分隔并插入颈静脉。与全分流相比，选择性地将门静脉血从肝脏分流可减少分流后肝脏萎缩、减轻体重减轻、改善尿素循环酶活性的维持、提高氨耐受性，并减少肝脏脱氧核糖核酸（DNA）、核糖核酸（RNA）和蛋白质含量的下降。左、右肝叶的分隔，无论是与门静脉或体静脉肝脏灌注有关，还是与胃十二指肠胰脾或肠道门静脉引流有关，对各肝叶的酶或蛋白质代谢影响很小。
