Riva J, Lejbusiewicz G, Papa M, Lauber C, Kohn W, Da Fonte M, Burgstaller H, Comellas C, Ayala W
Department and Chair of Anaesthesiology, Faculty of Medicine, University of Uruguay.
Paediatr Anaesth. 1997;7(3):191-6. doi: 10.1046/j.1460-9592.1997.d01-75.x.
The aim of this study was to assess oral premedication with midazolam in paediatric anaesthesia. Sedation, quality of induction, recovery time, acceptance and effects on gastric contents were analysed. This prospective, double blind, at random and controlled study was performed in 107 children, aged between three and ten years. They were divided into: group 1 (control, n = 29), group 2 (placebo) receiving 5 ml of water in the preoperative stage (n = 40), and group 3 (midazolam) with 0.75 mg.kg-1 midazolam by mouth (n = 38). Two children refused to take medication. In children aged five years or more (n = 48) of groups 2 and 3, acceptance of premedication was evaluated. The midazolam group showed a better level of sedation as compared with the placebo (P < 0.05). The recovery time was similar for the two groups. There were no statistically significant differences in gastric pH or residual volume among the three groups. It is concluded that midazolam given by mouth is an efficient and safe drug for premedication in paediatric anaesthesia.
本研究的目的是评估咪达唑仑用于小儿麻醉的口服术前用药情况。分析了镇静效果、诱导质量、恢复时间、接受度以及对胃内容物的影响。这项前瞻性、双盲、随机对照研究在107名3至10岁的儿童中进行。他们被分为：第1组（对照组，n = 29），第2组（安慰剂组）在术前阶段接受5毫升水（n = 40），第3组（咪达唑仑组）口服0.75毫克/千克咪达唑仑（n = 38）。两名儿童拒绝服药。对第2组和第3组中5岁及以上的儿童（n = 48）评估了术前用药的接受度。与安慰剂组相比，咪达唑仑组的镇静水平更好（P < 0.05）。两组的恢复时间相似。三组之间的胃pH值或残余量没有统计学上的显著差异。结论是，口服咪达唑仑是小儿麻醉术前用药的一种有效且安全的药物。
