Klír P, Pospísil J, Skala E, Dienstbier Z, Tachecí O
Strahlentherapie. 1977 Oct;153(10):711-5.
An increase was demonstrated of the antiheparin activity in the blood of rats after their total exposure to 200, 500 and 800 R and dogs exposed to 400 R. In the rats the increase of the antiheparin activity was directly dependent of the exposure used. The antiheparin activity increased up to 180 min after the exposure. In the irradiated dogs, there was also a strong increase in the antiheparin activity with a certain decrease 24 hrs after irradiation. A secondary increase was observed on the 7th, 10th and 13th days of the experiment. In the lymph of the irradiated dogs, the increase of the antiheparin activity was steeper than that in the blood itself. The results achieved could serve as a starting point for further investigations to answer the question of possible using these changes for diagnostic estimation of the biological degree of the radiation damage under different conditions.
将大鼠全身照射200、500和800伦琴以及犬照射400伦琴后，其血液中的抗肝素活性增强。在大鼠中，抗肝素活性的增强与所用照射剂量直接相关。照射后抗肝素活性升高可持续至180分钟。在受照射的犬中，抗肝素活性也显著增强，照射后24小时有一定程度下降。在实验的第7、10和13天观察到二次升高。在受照射犬的淋巴中，抗肝素活性的升高比血液本身更为明显。所获得的结果可作为进一步研究的起点，以回答在不同条件下利用这些变化对辐射损伤生物学程度进行诊断评估的可能性问题。
