Changes of the antiheparin activity of the blood plasma and lymph in dogs after total irradiation.

An increase was demonstrated of the antiheparin activity in the blood of rats after their total exposure to 200, 500 and 800 R and dogs exposed to 400 R. In the rats the increase of the antiheparin activity was directly dependent of the exposure used. The antiheparin activity increased up to 180 min after the exposure. In the irradiated dogs, there was also a strong increase in the antiheparin activity with a certain decrease 24 hrs after irradiation. A secondary increase was observed on the 7th, 10th and 13th days of the experiment. In the lymph of the irradiated dogs, the increase of the antiheparin activity was steeper than that in the blood itself. The results achieved could serve as a starting point for further investigations to answer the question of possible using these changes for diagnostic estimation of the biological degree of the radiation damage under different conditions.