Arroyo Villarino M T, Lanas Arbeloa A, Esteva Díaz F, Ortego Fernández de Retana J, Sainz Samitier R
Clinic University Hospital, Zaragoza, Spain.
Rev Esp Enferm Dig. 1997 May;89(5):347-56.
To compare the effects of long-term lansoprazole and omeprazole treatment (6 months) on serum gastrin levels.
Forty duodenal ulcer patients without previous treatment with proton pump inhibitors were randomized to receive either 20 mg/day or omeprazole or 30 mg/day of lansoprazole. Serum gastrin levels were determined on entry and every 2 months. On finalizing the study antral and fundic biopsies were obtained for immunohistochemical analysis of the enterochromaffin-like cell population.
Before starting the treatment fasting serum gastrin was similar in both groups (108.7 +/- 60.9 pg/mL omeprazole; 102.7 +/- 56.9 pg/mL lansoprazole). The treatment with either omeprazole or lansoprazole increased serum gastrin levels, but the increase was mild, maximal at 2 months and similar between omeprazole and lansoprazole (113.44 +/- 114.9 pg/mL omeprazole vs 166.1 +/- 117.9 pg/mL lansoprazole; p > 0.05). When serum gastrin levels were individually analyzed by patient, most were below 200 pg/mL and only 3 patients (1 omeprazole/2 lansoprazole) had levels near 500 pg/mL which were not correlated with enterochromaffin-like cell hyperplasia.
Long-term treatment with either omeprazole or lansoprazole is safe, at least during 6 months, and results in mild hypergastrinemia. No differences between these two drugs were observed.
比较长期（6个月）使用兰索拉唑和奥美拉唑治疗对血清胃泌素水平的影响。
40例未曾接受过质子泵抑制剂治疗的十二指肠溃疡患者被随机分为两组，分别接受每日20毫克奥美拉唑或每日30毫克兰索拉唑治疗。在入组时及每2个月测定血清胃泌素水平。在研究结束时，获取胃窦和胃底活检组织，用于对肠嗜铬样细胞群体进行免疫组织化学分析。
治疗开始前，两组患者的空腹血清胃泌素水平相似（奥美拉唑组为108.7±60.9皮克/毫升；兰索拉唑组为102.7±56.9皮克/毫升）。使用奥美拉唑或兰索拉唑治疗均使血清胃泌素水平升高，但升高幅度较小，在2个月时达到最大值，且奥美拉唑和兰索拉唑之间相似（奥美拉唑组为113.44±114.9皮克/毫升，兰索拉唑组为166.1±117.9皮克/毫升；p>0.05）。当对患者个体的血清胃泌素水平进行分析时，大多数患者低于200皮克/毫升，只有3例患者（1例使用奥美拉唑/2例使用兰索拉唑）的水平接近500皮克/毫升，且与肠嗜铬样细胞增生无关。
长期使用奥美拉唑或兰索拉唑治疗至少在6个月内是安全的，并导致轻度高胃泌素血症。未观察到这两种药物之间存在差异。
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