Camilo Silvia Maria Perrone, Almeida Élia Cláudia de Souza, Sousa Jacqueline Batista, Camilo Luana Perrone, Etchebehere Renata Margarida
Post-Graduate Program in Health Sciences, Clinical Hospital, Triângulo Mineiro Federal University, Uberaba, MG, Brazil.
Post-Graduate Program in Health Sciences, Triângulo Mineiro Federal University, Uberaba, MG, Brazil.
Arq Bras Cir Dig. 2020;33(2):e1506. doi: 10.1590/0102-672020190001e1506. Epub 2020 Aug 24.
Acid inhibition from chronic proton pump inhibitor use and a possible increase in gastrin can lead to changes in the regulation of hydrochloric acid production. However, it has not known whether such chronic use changes the presence of gastrin, delta, and enterochromaffin-like cells in the stomach or the relationship between gastrin and delta cells.
To analyze the number of gastrin-producing gastrin cells, somatostatin-producing cells, and histamine-producing cells in patients who were chronic users of proton pump inhibitor, with or without related Helicobacter pylori infection.
Biopsies from 105 patients, including 81 chronic proton pump inhibitor users (experimental group) and 24 controls, were processed immunohistochemically and subjected to counting of gastrin, delta, and enterochromaffin-like cells in high-magnification microscopic fields and in 10 glands.
Gastrin cell, delta cell, and enterochromaffin-like cells counts were similar across the groups and appeared to be unaffected by Helicobacter pylori infection. The ratio between gastrin cells and delta cells was higher in the chronic users of proton pump inhibitor group than in controls.
Chronic users of proton pump inhibitor does not affect gastrin cell, delta cell, and enterochromaffin-like cell counts significantly, but may alter the ratio between gastrin cells and delta cells.
长期使用质子泵抑制剂导致的酸抑制以及胃泌素可能的增加会引起盐酸分泌调节的变化。然而，尚不清楚这种长期使用是否会改变胃中胃泌素、δ细胞和肠嗜铬样细胞的存在情况，或者胃泌素与δ细胞之间的关系。
分析长期使用质子泵抑制剂的患者（无论是否伴有幽门螺杆菌感染）中产生胃泌素的胃泌素细胞、产生生长抑素的细胞和产生组胺的细胞的数量。
对105例患者的活检组织进行免疫组织化学处理，其中包括81例长期使用质子泵抑制剂的患者（实验组）和24例对照，在高倍显微镜视野下和10个腺体中对胃泌素、δ细胞和肠嗜铬样细胞进行计数。
各组间胃泌素细胞、δ细胞和肠嗜铬样细胞的计数相似，且似乎不受幽门螺杆菌感染的影响。质子泵抑制剂长期使用者组中胃泌素细胞与δ细胞的比例高于对照组。
长期使用质子泵抑制剂不会显著影响胃泌素细胞、δ细胞和肠嗜铬样细胞的计数，但可能会改变胃泌素细胞与δ细胞之间的比例。
