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Androgen receptor protein binding properties and tissue distribution of 2-selena-a-nor-5alpha-androstan-17beta-ol in the rat.

作者信息

Skinner R W, Pozderac R V, Counsell R E, Hsu C F, Weinhold P A

出版信息

Steroids. 1977 Jul;30(1):15-23. doi: 10.1016/0039-128x(77)90132-5.

DOI:10.1016/0039-128x(77)90132-5
PMID:919015
Abstract

2-selena-A-nor-5alpha-androstan-17beta-ol was studied in vitro and in vivo in the rat prostate gland. The data demonstrates the ability of this compound to selectively complex with the specific receptors of 5alpha-dihydrotestosterone (5alpha-DHT) in the cytosol and to be retained in the nuclei in an unaltered form. Studies with selenium-75 labeled material suggests that the uptake and localization is similar to endogenous 5alpha-dihydrotestosterone.

摘要

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