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Correlation of in vivo and in vitro activities of some naturally occurring androgens using a radioreceptor assay for 5alpha-dihydrotestosterone with rat prostate cytosol receptor protein.

作者信息

Grover P K, Odell W D

出版信息

J Steroid Biochem. 1975 Oct;6(10):1373-9. doi: 10.1016/0022-4731(75)90072-2.

DOI:10.1016/0022-4731(75)90072-2
PMID:1052837
Abstract
摘要

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1
Correlation of in vivo and in vitro activities of some naturally occurring androgens using a radioreceptor assay for 5alpha-dihydrotestosterone with rat prostate cytosol receptor protein.使用针对5α-双氢睾酮的放射受体分析法以及大鼠前列腺胞质溶胶受体蛋白，对某些天然存在的雄激素的体内和体外活性进行相关性研究。
J Steroid Biochem. 1975 Oct;6(10):1373-9. doi: 10.1016/0022-4731(75)90072-2.
2
Relative binding affinity of anabolic-androgenic steroids: comparison of the binding to the androgen receptors in skeletal muscle and in prostate, as well as to sex hormone-binding globulin.合成代谢雄激素类固醇的相对结合亲和力：与骨骼肌和前列腺中的雄激素受体以及性激素结合球蛋白的结合比较。
Endocrinology. 1984 Jun;114(6):2100-6. doi: 10.1210/endo-114-6-2100.
3
Pathways and genes involved in steroid hormone metabolism in male pigs: a review and update.雄性猪类固醇激素代谢途径和相关基因：综述与更新。
J Steroid Biochem Mol Biol. 2014 Mar;140:44-55. doi: 10.1016/j.jsbmb.2013.11.001. Epub 2013 Nov 12.
4
Formation of 5α-dihydrotestosterone from 5α-androstane-3α,17β-diol in prostate cancer LAPC-4 cells - Identifying inhibitors of non-classical pathways producing the most potent androgen.在前列腺癌 LAPC-4 细胞中，从 5α-雄烷-3α,17β-二醇形成 5α-二氢睾酮 - 鉴定产生最强雄激素的非经典途径抑制剂。
Bioorg Med Chem Lett. 2020 Jan 15;30(2):126783. doi: 10.1016/j.bmcl.2019.126783. Epub 2019 Nov 9.
5
Binding and metabolism of 5alpha-androstane-3alpha, 17 beta-diol and of 5alpha-androstane-3beta, 17 beta-diol in the prostate, seminal vesicles and plasma of male rats: studies in vivo and in vitro.5α-雄甾烷-3α,17β-二醇和5α-雄甾烷-3β,17β-二醇在雄性大鼠前列腺、精囊和血浆中的结合与代谢：体内和体外研究
J Endocrinol. 1975 Mar;64(3):529-38. doi: 10.1677/joe.0.0640529.
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Metabolism of [4-14C] testosterone in the rat uterus in vitro.大鼠子宫体外对[4-14C]睾酮的代谢
Eur J Biochem. 1975 Nov 1;59(1):305-12. doi: 10.1111/j.1432-1033.1975.tb02456.x.
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Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones.醛酮还原酶超家族的人类3α-羟基类固醇脱氢酶亚型（AKR1C1-AKR1C4）：功能可塑性和组织分布揭示其在雄性和雌性性激素失活与形成中的作用。
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7alpha-Iodo and 7alpha-fluoro steroids as androgen receptor-mediated imaging agents.7α-碘和7α-氟类固醇作为雄激素受体介导的显像剂。
J Med Chem. 1999 Jun 3;42(11):2021-34. doi: 10.1021/jm990064o.
9
5alpha-Androstane-3beta,17beta-diol (3beta-diol), an estrogenic metabolite of 5alpha-dihydrotestosterone, is a potent modulator of estrogen receptor ERbeta expression in the ventral prostrate of adult rats.5α-雄甾烷-3β,17β-二醇（3β-二醇）是5α-二氢睾酮的一种雌激素代谢产物，是成年大鼠腹侧前列腺中雌激素受体ERβ表达的有效调节剂。
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Simultaneous quantitation of nine hydroxy-androgens and their conjugates in human serum by stable isotope dilution liquid chromatography electrospray ionization tandem mass spectrometry.采用稳定同位素稀释液相色谱-电喷雾电离串联质谱法同时定量测定人血清中九种羟基雄激素及其共轭物。
J Steroid Biochem Mol Biol. 2017 Jan;165(Pt B):342-355. doi: 10.1016/j.jsbmb.2016.08.001. Epub 2016 Aug 12.

引用本文的文献

1
History of Adrenal Research: From Ancient Anatomy to Contemporary Molecular Biology.肾上腺研究史：从古代解剖学到当代分子生物学。
Endocr Rev. 2023 Jan 12;44(1):70-116. doi: 10.1210/endrev/bnac019.
2
Prenatal androgen treatment alters body composition and glucose homeostasis in male rats.产前雄激素处理改变雄性大鼠的身体成分和葡萄糖稳态。
J Endocrinol. 2011 Mar;208(3):293-300. doi: 10.1677/JOE-10-0263. Epub 2010 Dec 20.
3
5alpha-androstane-3alpha,17beta-diol selectively activates the canonical PI3K/AKT pathway: a bioinformatics-based evidence for androgen-activated cytoplasmic signaling.
5α-雄甾烷-3α,17β-二醇选择性激活经典PI3K/AKT信号通路：雄激素激活细胞质信号传导的基于生物信息学的证据
Genomic Med. 2007;1(3-4):139-46. doi: 10.1007/s11568-008-9018-9. Epub 2008 Feb 27.
4
The androgen 5alpha-dihydrotestosterone and its metabolite 5alpha-androstan-3beta, 17beta-diol inhibit the hypothalamo-pituitary-adrenal response to stress by acting through estrogen receptor beta-expressing neurons in the hypothalamus.雄激素5α-双氢睾酮及其代谢产物5α-雄甾烷-3β,17β-二醇通过作用于下丘脑表达雌激素受体β的神经元，抑制下丘脑-垂体-肾上腺对应激的反应。
J Neurosci. 2006 Feb 1;26(5):1448-56. doi: 10.1523/JNEUROSCI.3777-05.2006.
5
Prostate gland: structure, functions and regulation.前列腺：结构、功能与调节
Int Urol Nephrol. 1995;27(3):231-43. doi: 10.1007/BF02564756.
6
Binding of androgens to a nuclear-envelope fraction from the rat ventral prostate.雄激素与大鼠腹侧前列腺核膜组分的结合。
Biochem J. 1980 Mar 15;186(3):641-7. doi: 10.1042/bj1860641.
7
Orally administered melatonin stimulates the 3 alpha/beta-hydroxysteroid oxidoreductase but not the 5 alpha-reductase in the ventral prostate and seminal vesicles of pinealectomized rats.口服褪黑素可刺激松果体切除大鼠腹侧前列腺和精囊中的3α/β-羟基类固醇氧化还原酶，但不刺激5α-还原酶。
Experientia. 1982 Aug 15;38(8):968-70. doi: 10.1007/BF01953682.
8
Male hypogonadism.男性性腺功能减退
West J Med. 1976 Jun;124(6):446-75.
9
Mechanisms of replenishment of nuclear androgen receptor in rat ventral prostate.大鼠腹侧前列腺中核雄激素受体的补充机制
Biochem J. 1978 Jul 15;174(1):9-16. doi: 10.1042/bj1740009.