Discriminating among the discriminator bases of tRNAs.
作者信息
Hou Y M
机构信息
Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA.
出版信息
Chem Biol. 1997 Feb;4(2):93-6. doi: 10.1016/s1074-5521(97)90252-0.
PMID:9190291
Abstract
Aminoacyl-tRNA synthetases must select their specific tRNAs from the 20 structurally similar tRNAs present in a cell. The discriminator base, at position 73 of the tRNA, is important for this selection but its effects on aminoacylation are variable depending on context. Recent structural studies provide insight into this variability.
摘要
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