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[鸽子中分化红细胞的细胞膜空壳与质膜对醛缩酶的结合]

[Aldolase binding by ghosts and plasma membranes of differentiating erythroid cells in pigeons].

作者信息

Akhmedov A T, Mozhenok T P

出版信息

Tsitologiia. 1977;19(8):876-81.

PMID:919032
Abstract

During the differentiation of pigeon erythroid cells their aldolase activity considerably decreases, which is more obvious during the erythroblast reticulocyte development compared to the reticulocyte erythrocyte development. There are some common patterns in the character of aldolase binding by plasma membrane (PM) of the erythroid cells of different degrees of maturation: a high binding lability and the availability of a small portion of enzyme firmly bound to PM. During erythropoesis an increase of aldolase binding occurs. The provided data show a specific character of interaction of aldolase with erythroid membrane. The shown increase of aldolase binding may partly explain a decrease of its activity in the course of erythropoesis and is, perhaps, of adaptive character.

摘要

在鸽类红细胞的分化过程中,它们的醛缩酶活性显著降低,与网织红细胞向红细胞发育阶段相比,这种降低在成红细胞向网织红细胞发育阶段更为明显。不同成熟度的红细胞质膜(PM)对醛缩酶的结合特性存在一些共同模式:结合不稳定性高,且有一小部分酶牢固地结合在质膜上。在红细胞生成过程中,醛缩酶的结合增加。所提供的数据表明醛缩酶与红细胞膜相互作用具有特异性。所显示的醛缩酶结合增加可能部分解释了其在红细胞生成过程中活性的降低,并且可能具有适应性特征。

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