Byshevskyj A S, Rudzevych E L
Ukr Biokhim Zh. 1977 Sep-Oct;49(5):27-31.
The ability of human blood serum for inactivating tissue thromboplastin is established to be due to the presence of two inhibitors: thermolabile inhibitor characterized by a progressive effect and thermostable one having an instant effect. Thromboplastin inhibition by the thermolabile inhibitor is partial, whereas inhibition by the thermostable one is completely reversible. In the latter case inhibition is intermediate character, between the competitive and incompetitive one. The inhibitory activity is found in Cohn's fraction V, is removed during DEAE-cellulos chromatography and gel chromatography with the first portions of eluating liquid.
一种是具有渐进作用的热不稳定抑制剂，另一种是具有即时作用的热稳定抑制剂。热不稳定抑制剂对凝血活酶的抑制作用是部分性的，而热稳定抑制剂的抑制作用是完全可逆的。在后一种情况下，抑制作用具有介于竞争性和非竞争性之间的中间特性。抑制活性存在于科恩氏Ⅴ组分中，在二乙氨基乙基纤维素色谱法和凝胶色谱法中，随着洗脱液的第一部分被去除。
