Fullerton W W, Boggust W A, O'Meara R A
J Clin Pathol. 1967 Jul;20(4):624-8. doi: 10.1136/jcp.20.4.624.
In the course of systematic research into the coagulative properties of cancers, facts of wider implication on the behaviour of fatty acids in relation to clotting have been uncovered. It has been shown that saturated fatty acids of appropriate chain length have a direct inhibitory effect on tissue thromboplastins with an optimum of 14 carbon atoms. Unsaturated fatty acids have a similar, though more marked, inhibitory activity with an optimum chain length of 16 carbon atoms. The inhibitory activity is reduced by combining the acids with human serum albumin. Certain fatty acids when dissolved in human serum albumin form labile thromboplastins with properties corresponding to those found in human cancers and in chorion.
在对癌症凝血特性的系统研究过程中，发现了脂肪酸与凝血相关行为的更广泛影响因素。研究表明，具有适当链长的饱和脂肪酸对组织凝血活酶有直接抑制作用，最佳链长为14个碳原子。不饱和脂肪酸具有类似但更显著的抑制活性，最佳链长为16个碳原子。将这些酸与人血清白蛋白结合会降低其抑制活性。某些脂肪酸溶解于人血清白蛋白中时会形成不稳定的凝血活酶，其性质与在人类癌症和绒毛膜中发现的凝血活酶性质相对应。
