Mikhaĭlova A, Antov G, Khalkova Zh, Zaĭkov Kh, Tasheva M, Dinoeva S
Probl Khig. 1996;21:88-96.
The subacute (30 day) oral toxicity of Gastrofenzin has been investigated in white rats "Wistar" of both sexes, treated with 0.7 and 33 mg.kg-1 for the male and 0.9 and 44 mg.kg-1 for the female rats. The applied doses respond respectively to the control doses, 1/100 and 1/20 LD50 of the preparation. A complex of integral, behaviour, laboratory biochemical and histological methods has been used. The findings show that Gastrofenzin in doses 1/100 and 1/20 LD50 does not exert cumulative effect, reported by the lack of lethal effect among the animals. With the help of actograph "AIDA" an increased spontaneous activity is reported in the rats from both sexes treated with dose 1/20 LD50 of the preparation. Under the experimental conditions the doses of 7 and 9 mg.kg-1 (1/100 LD50) and 33 and 44 mg.kg-1 (1/20 LD50) do not exert toxic effect on the liver, kidneys and brain. Deviations are observed which show increasing of the oxidative-metabolic processes and trigger adaptation mechanisms in the above mentioned organs.
已在雌雄“Wistar”大白鼠中研究了胃复安的亚急性（30天）口服毒性，雄性大鼠的给药剂量为0.7和33毫克/千克，雌性大鼠为0.9和44毫克/千克。所施用的剂量分别相当于该制剂对照剂量的1/100和1/20 LD50。采用了综合、行为、实验室生化和组织学方法。研究结果表明，剂量为1/100和1/20 LD50的胃复安未产生累积效应，这体现在动物中未出现致死效应。借助活动记录仪“AIDA”，发现用该制剂1/20 LD50剂量处理的雌雄大鼠的自发活动增加。在实验条件下，7和9毫克/千克（1/100 LD50）以及33和44毫克/千克（1/20 LD50）的剂量对肝脏、肾脏和大脑未产生毒性作用。观察到有偏差，表明上述器官的氧化代谢过程增强并触发了适应机制。
