Pluskiewicz W, Rogala E
Katedry i Kliniki Chorób Wewnetrznych i Alergologii, Zabrze.
Przegl Lek. 1997;54(1):21-4.
The aim of the trial was estimation of frequency and degree of osteoporosis in steroid-dependent asthma patients (48 persons: 18 men and 30 women). Control group created 36 healthy persons. Following measurements were done: quantitative computed tomography, radiological estimation of thoracic and lumbal spinal column and hands, in serum total alkaline phosphatase, calcium, phosphate, in urine excretion of calcium, phosphate and creatinine. Quantitative computer tomography revealed secondary osteoporosis in 40.5% asthma patients. These results were correlated with estimation of roentgenograms of thoracic and lumbal spinal column and metacarpal measurements and less well with total alkaline phosphatase. Time of duration of steroid therapy and time of asthma had influence on degree of osteoporosis. Moderate development of osteoporosis is probably the result of low dose of steroids.
该试验的目的是评估依赖类固醇的哮喘患者（48人，其中18名男性和30名女性）骨质疏松症的发生率和严重程度。对照组由36名健康人组成。进行了以下测量：定量计算机断层扫描、胸部和腰椎脊柱及手部的放射学评估、血清总碱性磷酸酶、钙、磷酸盐、尿钙、磷酸盐和肌酐排泄量。定量计算机断层扫描显示40.5%的哮喘患者存在继发性骨质疏松症。这些结果与胸部和腰椎脊柱X线片评估及掌骨测量结果相关，与总碱性磷酸酶的相关性稍弱。类固醇治疗持续时间和哮喘病程对骨质疏松症的严重程度有影响。骨质疏松症的中度发展可能是低剂量类固醇的结果。
