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鼠伤寒沙门氏菌ahp操纵子作为巨噬细胞诱导位点的鉴定。

Identification of the ahp operon of Salmonella typhimurium as a macrophage-induced locus.

作者信息

Francis K P, Taylor P D, Inchley C J, Gallagher M P

机构信息

Division of Biology, University of Edinburgh, Scotland.

出版信息

J Bacteriol. 1997 Jun;179(12):4046-8. doi: 10.1128/jb.179.12.4046-4048.1997.

DOI:10.1128/jb.179.12.4046-4048.1997
PMID:9190824
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC179217/
Abstract

Previously, we tagged a macrophage-induced Salmonella typhimurium locus with Mudlux (K. P. Francis and M. P. Gallagher, Infect. Immun. 61:640-649, 1993). The insertion lies within the OxyR-regulated ahpC locus and conveys alkyl peroxide sensitivity. Plasmid-encoded ahp reverses sensitivity but reduces luminescence. This suggests that OxyR is titrated by the multicopy ahp promoter.

摘要

此前，我们用Mudlux标记了一个巨噬细胞诱导的鼠伤寒沙门氏菌基因座（K. P. 弗朗西斯和M. P. 加拉格尔，《感染与免疫》61:640 - 649，1993年）。插入位点位于受OxyR调控的ahpC基因座内，并赋予细胞对烷基过氧化物的敏感性。质粒编码的ahp可逆转敏感性，但会降低发光强度。这表明OxyR被多拷贝的ahp启动子滴定。

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J Bacteriol. 1997 Jun;179(12):4046-8. doi: 10.1128/jb.179.12.4046-4048.1997.
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本文引用的文献

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Green fluorescent protein as a marker for gene expression and cell biology of mycobacterial interactions with macrophages.绿色荧光蛋白作为分枝杆菌与巨噬细胞相互作用的基因表达和细胞生物学的标志物。
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