鼠伤寒沙门氏菌ahp操纵子作为巨噬细胞诱导位点的鉴定。
Identification of the ahp operon of Salmonella typhimurium as a macrophage-induced locus.
作者信息
Francis K P, Taylor P D, Inchley C J, Gallagher M P
机构信息
Division of Biology, University of Edinburgh, Scotland.
出版信息
J Bacteriol. 1997 Jun;179(12):4046-8. doi: 10.1128/jb.179.12.4046-4048.1997.
Abstract
Previously, we tagged a macrophage-induced Salmonella typhimurium locus with Mudlux (K. P. Francis and M. P. Gallagher, Infect. Immun. 61:640-649, 1993). The insertion lies within the OxyR-regulated ahpC locus and conveys alkyl peroxide sensitivity. Plasmid-encoded ahp reverses sensitivity but reduces luminescence. This suggests that OxyR is titrated by the multicopy ahp promoter.
摘要
此前，我们用Mudlux标记了一个巨噬细胞诱导的鼠伤寒沙门氏菌基因座（K. P. 弗朗西斯和M. P. 加拉格尔，《感染与免疫》61:640 - 649，1993年）。插入位点位于受OxyR调控的ahpC基因座内，并赋予细胞对烷基过氧化物的敏感性。质粒编码的ahp可逆转敏感性，但会降低发光强度。这表明OxyR被多拷贝的ahp启动子滴定。
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