Loiseau P, Mariotti M, Corbi C, Ravera N, Girot R, Thauvin M, Portelette E, Mariette X, Roudot-Thoraval F, Benbunan M, Lefrère J J
Etablissement de Transfusion Sanguine de l'Assistance Publique-Hôpitaux de Paris (AP-HP), Site Saint-Louis, France.
Transfusion. 1997 Jun;37(6):645-50. doi: 10.1046/j.1537-2995.1997.37697335161.x.
Recently, cases of chronic hepatitis were linked to the presence of genomic sequences of a newly described RNA virus termed hepatitis G virus (HGV) and belonging to the Flaviviridae family.
The presence of HGV RNA was searched for by polymerase chain reaction in a population of blood donors and in patients who had received multiple blood component transfusions and/or intravenous immunoglobulin (IVIG) infusions.
Twenty-one (4.2%) of 500 donors were positive for HGV RNA as were 21 (10.7%) of 196 nonimmunosuppressed patients who had received multiple transfusions of packed red cells, 4 (8.7%) of 46 common variable immune deficiency (CVID) patients who had received only IVIG, and 22 (24.7%) of 89 bone marrow transplant (BMT) patients who had received IVIG and cellular components. The proportion of HGV-positive individuals was significantly higher in the immunosuppressed recipients (CVID and BMT patients) than in the nonimmunosuppressed patients who were multiply transfused with packed red cells (p < 0.03). The proportion of HGV-positive individuals was significantly higher in the BMT patients who had received IVIG and cellular components than in the CVID patients who had received IVIG only (p < 0.03). Eight (17.0%) of the 47 HGV-positive recipients and 48 (16.9%) of the 284 HGV-negative recipients had a serum alanine aminotransferase level higher than the upper limit of normal (nonsignificant difference). The medical history of HGV-positive donors failed to reveal a particular at-risk event. The large majority of HGV-infected patients had a normal serum alanine aminotransferase level, and the proportion of patients with elevated alanine aminotransferase was the same in HGV-positive and in HGV-negative recipients.
The pathological significance of HGV infection remains unelucidated, and the classification of HGV as a new hepatitis virus was perhaps premature.
最近，慢性肝炎病例与一种新描述的RNA病毒——庚型肝炎病毒（HGV）的基因组序列有关，该病毒属于黄病毒科。
通过聚合酶链反应在献血者群体以及接受多次血液成分输血和/或静脉注射免疫球蛋白（IVIG）的患者中检测HGV RNA的存在情况。
500名献血者中有21名（4.2%）HGV RNA呈阳性，196名接受多次红细胞悬液输血的非免疫抑制患者中有21名（10.7%）呈阳性，46名仅接受IVIG的常见可变免疫缺陷（CVID）患者中有4名（8.7%）呈阳性，89名接受IVIG和细胞成分的骨髓移植（BMT）患者中有22名（24.7%）呈阳性。免疫抑制受者（CVID和BMT患者）中HGV阳性个体的比例显著高于多次接受红细胞悬液输血的非免疫抑制患者（p < 0.03）。接受IVIG和细胞成分的BMT患者中HGV阳性个体的比例显著高于仅接受IVIG的CVID患者（p < 0.03）。47名HGV阳性受者中有8名（17.0%）血清丙氨酸氨基转移酶水平高于正常上限，284名HGV阴性受者中有48名（16.9%）高于正常上限（无显著差异）。HGV阳性献血者的病史未显示出特定的高危事件。大多数HGV感染患者血清丙氨酸氨基转移酶水平正常，HGV阳性和阴性受者中丙氨酸氨基转移酶升高患者的比例相同。
HGV感染的病理意义仍未阐明，将HGV归类为一种新型肝炎病毒可能为时过早。
