Chabance B, Qian Z Y, Migliore-Samour D, Jollès P, Fiat A M
Laboratoire des Protéines, CNRS URA 1188, Université de Paris V, France.
Biochem Mol Biol Int. 1997 Jun;42(1):77-84. doi: 10.1080/15216549700202451.
The bovine caseinoglycopeptide (residues 106-169), the C-terminal part of kappa-casein, inhibited the von Willebrand factor-dependent platelet aggregation in a dose-dependent manner. An affinity matrix made of the caseinoglycopeptide selectively bound the platelet membrane glycoprotein GPIb alpha which contains the von Willebrand factor binding site. The amino acid residues of GPIb alpha participating in the caseinoglycopeptide binding were located after residue Glu 90.
牛酪蛋白糖肽（κ-酪蛋白的C末端部分，残基106 - 169）以剂量依赖的方式抑制血管性血友病因子依赖性血小板聚集。由酪蛋白糖肽制成的亲和基质选择性结合含有血管性血友病因子结合位点的血小板膜糖蛋白GPIbα。参与酪蛋白糖肽结合的GPIbα氨基酸残基位于Glu 90残基之后。
