[胰岛素及胰岛素缺乏对兔胃平滑肌中己糖激酶、苹果酸脱氢酶、乳酸脱氢酶及其同工酶组成活性的影响]
[Effect of insulin and insulin deficiency on the activity of hexokinase, malate dehydrogenase, lactate dehydrogenase and its isoenzyme composition in the smooth muscle of the rabbit stomach].
作者信息
Il'in V S, Saskian I L, Pleskov V M
出版信息
Vopr Med Khim. 1977 Jul-Aug;23(4):515-9.
Decrease in the activity of hexokinase was found in soluble fraction of stomach smooth muscles of rabbits with alloxane diabetes. Administration of insulin into intact rabbits led to distinct decrease in the activity of lactate and malate dehydrogenases in cells of the stomach fundal part. In smooth muscles of rabbits with alloxane diabetes pyruvate was formed from lactate at a higher rate (increase in content of LDH1 and LDH2) and after administration of insulin into the animals--lactate was formed from pyruvate at an increased rate.
在患有四氧嘧啶糖尿病的兔子的胃平滑肌可溶性部分中发现己糖激酶活性降低。对正常兔子注射胰岛素导致胃底部细胞中乳酸脱氢酶和苹果酸脱氢酶的活性明显降低。在患有四氧嘧啶糖尿病的兔子的平滑肌中，乳酸生成丙酮酸的速率更高（LDH1和LDH2含量增加），而给动物注射胰岛素后，丙酮酸生成乳酸的速率增加。
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