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A model of Plasmodium falciparum lactate dehydrogenase and its implications for the design of improved antimalarials and the enhanced detection of parasitaemia.

作者信息

Sessions R B, Dewar V, Clarke A R, Holbrook J J

机构信息

Molecular Recognition Centre, University of Bristol School of Medical Sciences, UK.

出版信息

Protein Eng. 1997 Apr;10(4):301-6. doi: 10.1093/protein/10.4.301.

DOI:10.1093/protein/10.4.301
PMID:9194154
Abstract
摘要

相似文献

1
A model of Plasmodium falciparum lactate dehydrogenase and its implications for the design of improved antimalarials and the enhanced detection of parasitaemia.恶性疟原虫乳酸脱氢酶模型及其对改进抗疟药物设计和增强寄生虫血症检测的意义。
Protein Eng. 1997 Apr;10(4):301-6. doi: 10.1093/protein/10.4.301.
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Substrate and cofactor specificity and selective inhibition of lactate dehydrogenase from the malarial parasite P. falciparum.恶性疟原虫乳酸脱氢酶的底物、辅因子特异性及选择性抑制作用
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Mapping the binding site for gossypol-like inhibitors of Plasmodium falciparum lactate dehydrogenase.绘制恶性疟原虫乳酸脱氢酶的棉酚样抑制剂的结合位点图谱。
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Protein engineering tests of a homology model of Plasmodium falciparum lactate dehydrogenase.恶性疟原虫乳酸脱氢酶同源模型的蛋白质工程测试。
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Plasmodium and host lactate dehydrogenase molecular function and biological pathways: implication for antimalarial drug discovery.疟原虫与宿主乳酸脱氢酶的分子功能及生物学途径：对抗疟药物研发的启示
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The structure of lactate dehydrogenase from Plasmodium falciparum reveals a new target for anti-malarial design.恶性疟原虫乳酸脱氢酶的结构揭示了抗疟疾设计的新靶点。
Nat Struct Biol. 1996 Nov;3(11):912-5. doi: 10.1038/nsb1196-912.
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An alpha-proteobacterial type malate dehydrogenase may complement LDH function in Plasmodium falciparum. Cloning and biochemical characterization of the enzyme.一种α-变形菌属型苹果酸脱氢酶可能补充恶性疟原虫中乳酸脱氢酶的功能。该酶的克隆及生化特性分析。
Eur J Biochem. 2004 Sep;271(17):3488-502. doi: 10.1111/j.1432-1033.2004.04281.x.
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Chloroquine binds in the cofactor binding site of Plasmodium falciparum lactate dehydrogenase--a response.氯喹结合于恶性疟原虫乳酸脱氢酶的辅因子结合位点——一种反应。
Parasitol Today. 2000 Mar;16(3):133. doi: 10.1016/s0169-4758(99)01552-5.
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Design, synthesis, and biological evaluation of Plasmodium falciparum lactate dehydrogenase inhibitors.恶性疟原虫乳酸脱氢酶抑制剂的设计、合成及生物学评价
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10
Chloroquine binds in the cofactor binding site of Plasmodium falciparum lactate dehydrogenase.氯喹结合在恶性疟原虫乳酸脱氢酶的辅因子结合位点。
J Biol Chem. 1999 Apr 9;274(15):10213-8.

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