主要组织相容性复合体与经典血友病中对凝血因子VIII免疫反应之间的可能联系。
Possible linkage between the major histocompatibility complex and the immune response to factor VIII in classic haemophilia.
作者信息
Frommel D, Muller J Y, Prou-Wartelle O, Allain J P
出版信息
Vox Sang. 1977;33(5):270-2. doi: 10.1111/j.1423-0410.1977.tb04473.x.
Abstract
The pattern of HLA segregation was analyzed in 10 sibships of haemophilia A patients, each of which included 1 or 2 haemophilic brothers with an antibody to factor VIII. The observed HLA distribution is suggestive of a linkage between the major histocompatibility complex and a gene responsible for immune response to isologous factor VIII.
摘要
对10个甲型血友病患者的同胞关系进行了HLA分离模式分析，每个同胞关系中有1或2个患有血友病的兄弟，他们对凝血因子VIII产生了抗体。观察到的HLA分布表明，主要组织相容性复合体与一个负责对同种凝血因子VIII产生免疫反应的基因之间存在联系。
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