Honda H, Ishihara H, Takei M, Kogo H
Department of Pharmacology, Tokyo University of Pharmacy and Life Science, Japan.
Jpn J Pharmacol. 1997 May;74(1):113-5. doi: 10.1254/jjp.74.113.
Acetylcholine (ACh)-induced relaxation in the aortae precontracted with norepinephrine was significantly enhanced in the aortae from estrus (E) rats, compared with that in those from metestrus (D-1), diestrus (D-2) and proestrus (PE) rats. NG-Nitro-L-arginine methyl ester (L-NAME) inhibited the endothelium-dependent relaxation in E rats. These results suggest that there is a difference in ACh-induced relaxation of the thoracic aorta during the sexual cycle of rats, and the relaxation is greatest in E of the sexual cycle; this may be due to a difference in nitric oxide synthesis in the endothelium in the sexual cycle.
与动情后期（D-1）、动情间期（D-2）和动情前期（PE）大鼠相比，用去甲肾上腺素预收缩的发情期（E）大鼠主动脉中，乙酰胆碱（ACh）诱导的舒张作用显著增强。NG-硝基-L-精氨酸甲酯（L-NAME）抑制E期大鼠的内皮依赖性舒张。这些结果表明，大鼠性周期中胸主动脉对ACh诱导的舒张存在差异，且在性周期的E期舒张作用最强；这可能是由于性周期中内皮一氧化氮合成存在差异。
