Honda H, Ushijima D, Ishihara H, Yanase M, Kogo H
Department of Pharmacology, Tokyo University of Pharmacy and Life Science, Japan.
Physiol Behav. 1997 Dec 31;63(1):55-8. doi: 10.1016/s0031-9384(97)00388-0.
The tension of the isolated thoracic aorta of the rat was measured isometrically to determine if there is a regional variation of the relaxation to acetylcholine (ACh). Endothelium-derived nitric oxide (NO)-dependent relaxation to ACh in the thoracic aorta precontracted with norepinephrine was significantly greater in the middle and distal segments than in the proximal segments. The relaxation to ACh was inhibited by NG-nitro-L-arginine methyl ester, an inhibitor of NO synthase. The relaxation to the NO donor sodium nitroprusside did not differ between the same three segments of the thoracic aorta. These results suggest that there are regional variations in the ACh-induced release of endothelium-derived NO in the rat thoracic aorta.
通过等长测量大鼠离体胸主动脉的张力，以确定对乙酰胆碱（ACh）的舒张反应是否存在区域差异。用去甲肾上腺素预收缩的胸主动脉中，中、远段对ACh的内皮源性一氧化氮（NO）依赖性舒张反应显著大于近段。ACh诱导的舒张反应被NO合酶抑制剂NG-硝基-L-精氨酸甲酯抑制。胸主动脉相同的三段对NO供体硝普钠的舒张反应无差异。这些结果表明，大鼠胸主动脉中ACh诱导的内皮源性NO释放存在区域差异。
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