Hörmann H, Jilek F
Wien Klin Wochenschr. 1977 Nov 11;89(21):728-9.
Cold-insoluble globulin (CIG) of plasma represents the soluble form of a fibroblast surface protein. As shown by affinity chromatography it is selectively adsorbed from plasma on immobilized collagen of various types. The following sequence of binding strength between CIG and collagen was evaluated by means of fractionated elution: collagen type III native less than type I native less than type I denatured. The affinity to native collagen is important for the capability of CIG to mediate the attachement of fibroplasts on collagen fibrils. In addition, CIG is a substrate of activated coagulation factor XIII which plays an important, but as yet unclarified role in wound healing.
血浆冷不溶性球蛋白（CIG）代表成纤维细胞表面蛋白的可溶形式。如亲和层析所示，它可从血浆中被选择性吸附到各种类型的固定化胶原蛋白上。通过分级洗脱评估了CIG与胶原蛋白之间的以下结合强度顺序：Ⅲ型天然胶原蛋白＜Ⅰ型天然胶原蛋白＜Ⅰ型变性胶原蛋白。对天然胶原蛋白的亲和力对于CIG介导成纤维细胞附着于胶原纤维的能力很重要。此外，CIG是活化凝血因子XIII的底物，该因子在伤口愈合中起重要但尚未明确的作用。
