Brezinski M E, Tearney G J, Weissman N J, Boppart S A, Bouma B E, Hee M R, Weyman A E, Swanson E A, Southern J F, Fujimoto J G
Massachusetts General Hospital and Harvard Medical School, Boston, USA.
Heart. 1997 May;77(5):397-403. doi: 10.1136/hrt.77.5.397.
OCT can image plaque microstructure at a level of resolution not previously demonstrated with other imaging techniques because it uses infrared light rather than acoustic waves.
To compare optical coherence tomography (OCT) and intravascular ultrasound (IVUS) imaging of in vitro atherosclerotic plaques.
Segments of abdominal aorta were obtained immediately before postmortem examination. Images of 20 sites from five patients were acquired with OCT (operating at an optical wavelength of 1300 nm which was delivered to the sample through an optical fibre) and a 30 MHz ultrasonic transducer. After imaging, the microstructure of the tissue was assessed by routine histological processing.
OCT yielded superior structural information in all plaques examined. The mean (SEM) axial resolution of OCT and IVUS imaging was 16 (1) and 110 (7), respectively, as determined by the point spread function from a mirror. Furthermore, the dynamic range of OCT was 109 dB compared with 43 dB for IVUS imaging.
OCT represents a promising new technology for intracoronary imaging because of its high resolution, broad dynamic range, and ability to be delivered through intravascular catheters.
光学相干断层扫描（OCT）能够以其他成像技术前所未有的分辨率对斑块微观结构进行成像，因为它使用的是红外光而非声波。
比较体外动脉粥样硬化斑块的光学相干断层扫描（OCT）和血管内超声（IVUS）成像。
在尸检前立即获取腹主动脉节段。使用OCT（工作在1300nm光波长，通过光纤传输到样本）和30MHz超声换能器对5名患者的20个部位进行成像。成像后，通过常规组织学处理评估组织的微观结构。
在所有检查的斑块中，OCT产生了更优的结构信息。通过镜子的点扩散函数确定，OCT和IVUS成像的平均（标准误）轴向分辨率分别为16（1）和110（7）。此外，OCT的动态范围为109dB，而IVUS成像为43dB。
由于OCT具有高分辨率、宽动态范围以及能够通过血管内导管进行传输的能力，它是一种用于冠状动脉成像的有前景的新技术。
