Tauchnitz C
Z Gesamte Inn Med. 1977 Jul 15;32(14):Suppl 219-22.
Reasons for the use of antibacterial combinations are synergistic effects and delayed development of bacterial resistance. On the basis of numerous experiments in vitro the opinion is supported that a clinically useful synergism depends on the addition of an aminoglycoside, the second compound being either one of the penicillins or cephalosporins, or a polymyxin, or a bacteriostatic agent like tetracycline, macrolide, and lincomycine. The decrease of MBC and MIC values varies according to the species and strains of bacteria and in dependence on the components of antibiotic combinations. Combination therapy with antibacterial synergism is indicated in life-threatening infections and in order to suppress bacterial persistences. Combinations with antagonistic effects should be avoided. The use of multiple antibiotics for broader spectrum only is not supported.
使用抗菌药物联合的原因是协同作用以及延缓细菌耐药性的产生。基于大量体外实验，以下观点得到支持：临床上有用的协同作用取决于添加一种氨基糖苷类药物，第二种药物可以是青霉素类、头孢菌素类中的一种，或者多粘菌素，或者是四环素、大环内酯类和林可霉素等抑菌剂。MBC和MIC值的降低因细菌种类和菌株而异，并取决于抗生素联合的成分。具有抗菌协同作用的联合治疗适用于危及生命的感染以及为了抑制细菌持续存在的情况。应避免使用具有拮抗作用的联合。不支持仅为了更广泛的抗菌谱而使用多种抗生素。
