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微管动力学:踏车运动再度兴起。

Microtubule dynamics: treadmilling comes around again.

作者信息

Waterman-Storer C M, Salmon E D

机构信息

Department of Biology, CB# 3280, 607 Fordham Hall, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

出版信息

Curr Biol. 1997 Jun 1;7(6):R369-72. doi: 10.1016/s0960-9822(06)00177-1.

DOI:10.1016/s0960-9822(06)00177-1
PMID:9197225
Abstract

Although it is generally believed that microtubules have minus ends bound to the centrosome and free plus ends that exhibit dynamic instability, recent observations show that the minus ends can be free and that modulation of dynamic instability at both ends can result in treadmilling and flux in interphase cells.

摘要

虽然人们普遍认为微管的负端与中心体相连,正端自由且表现出动态不稳定性,但最近的观察表明,负端也可以是自由的,并且两端动态不稳定性的调节可导致间期细胞中的踏车行为和物质流。

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