Moghaddam A, Rosenzweig M, Lee-Parritz D, Annis B, Johnson R P, Wang F
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA.
Science. 1997 Jun 27;276(5321):2030-3. doi: 10.1126/science.276.5321.2030.
Epstein-Barr virus (EBV) is a human lymphocryptovirus that causes infectious mononucleosis, persists asymptomatically for life in nearly all adults, and is associated with the development of B cell lymphomas and nasopharyngeal carcinomas. A highly similar rhesus lymphocryptovirus naturally endemic in rhesus monkeys was used to orally infect naïve animals from a pathogen-free colony. This animal model reproduced key aspects of human EBV infection, including oral transmission, atypical lymphocytosis, lymphadenopathy, activation of CD23(+) peripheral blood B cells, sustained serologic responses to lytic and latent EBV antigens, latent infection in the peripheral blood, and virus persistence in oropharyngeal secretions. This system may be useful for studying the pathogenesis, prevention, and treatment of EBV infection and associated oncogenesis.
爱泼斯坦-巴尔病毒（EBV）是一种人类淋巴细胞病毒，可引起传染性单核细胞增多症，几乎在所有成年人中无症状终身持续存在，并与B细胞淋巴瘤和鼻咽癌的发生有关。一种与恒河猴自然地方性流行的高度相似的恒河猴淋巴细胞病毒被用于经口感染来自无病原体群体的未接触过该病毒的动物。这个动物模型再现了人类EBV感染的关键特征，包括经口传播、非典型淋巴细胞增多、淋巴结病、CD23(+)外周血B细胞活化、对裂解性和潜伏性EBV抗原的持续血清学反应、外周血潜伏感染以及病毒在口咽分泌物中的持续存在。该系统可能有助于研究EBV感染及其相关肿瘤发生的发病机制、预防和治疗。
