Tyson D L, Landin L M, David R, Yoon D J
Division of Pediatric Endocrinology, New York University School of Medicine, New York, USA.
Biol Neonate. 1997;71(6):379-84. doi: 10.1159/000244439.
Testicular immunoreactive arginine vasopressin (irAVP) has been shown to inhibit testosterone production by the Leydig cell in vitro. We studied pre- and postpubertal rats and the results are in agreement with the notion that such inhibition might occur in vivo and, therefore, could have physiological significance. Testicular irAVP and serum testosterone levels were measured in 14-, 21-, 28-, 35-, 42-, and 70-day-old rats. The testicular irAVP concentration was lowest in early prepubertal rats, increased significantly to the highest level at 35 days, then decreased at 42 days, and plateaued at 70 days of age. A pubertal increase in serum testosterone was observed at 42 days when AVP was decreasing. Thus, an inverse relationship was observed at the onset of pubertal maturation. These parameters were also measured in 3 groups of rats 1 week after hemicastration which was performed at the ages of 28, 35 and 70 days. In the 28-day-old rats there was a significant decrease in irAVP 1 week later, in contrast to the intact animal, whereas hemicastration performed at 35 and 70 days of age had no impact on irAVP. Our data suggest that the role of AVP may be physiologically relevant during the peripubertal period of testicular maturation in the rat.
睾丸免疫反应性精氨酸加压素（irAVP）已被证明在体外可抑制睾丸间质细胞产生睾酮。我们对青春期前和青春期后的大鼠进行了研究，结果与这种抑制可能在体内发生的观点一致，因此可能具有生理意义。我们测定了14日龄、21日龄、28日龄、35日龄、42日龄和70日龄大鼠的睾丸irAVP和血清睾酮水平。睾丸irAVP浓度在青春期前早期大鼠中最低，在35天时显著升高至最高水平，然后在42天时下降，并在70日龄时趋于平稳。在42天时观察到血清睾酮在青春期增加，而此时AVP正在下降。因此，在青春期成熟开始时观察到了一种负相关关系。我们还对在28日龄、35日龄和70日龄进行半侧睾丸切除术后1周的3组大鼠测量了这些参数。与完整动物相比，28日龄大鼠在1周后irAVP显著降低，而在35日龄和70日龄进行半侧睾丸切除术对irAVP没有影响。我们的数据表明，在大鼠睾丸成熟的青春期前后，AVP的作用可能具有生理相关性。
