Silvestri F, Bussani R, Pavletic N, Mannone T, Bosatra A
Institute of Pathological Anatomy, University of Trieste, Italy.
Acta Otolaryngol Suppl. 1997;527:49-51. doi: 10.3109/00016489709124034.
Ki67 immunoreactivity, p53 expression and apoptotic index were examined in 26 non-malignant lesions of the head and neck region, 22 dysplastic lesions of patients without evidence of head and neck carcinoma during follow-up time, 24 dysplastic lesions of patients who subsequently developed a squamous carcinoma in the same area, and 42 squamous cancer cases. A directly proportional relation between Ki67 immunoreactive pattern, apoptotic index and histological evolution from normal to dysplastic or neoplastic mucosa was evident. As far as p53 protein is concerned, its expression became higher and frequently transmural in neoplastic mucosa. A strict correlation between frequency and density of Ki67/p53 immunoreactivity according to invasive cell grading (ICG) scores and poor prognosis of patients were found. On the contrary, malignant cells highly expressing p53 seemed not to undergo apoptosis. Ki67 antigen and p53 protein detection in premalignant lesions and in carcinomas of the head and neck tract could be a useful marker for the management of patients at risk.
在26例头颈部非恶性病变、22例随访期间无头颈癌证据的发育异常病变、24例随后在同一区域发生鳞状癌的发育异常病变以及42例鳞状癌病例中检测了Ki67免疫反应性、p53表达和凋亡指数。Ki67免疫反应模式、凋亡指数与从正常黏膜到发育异常或肿瘤性黏膜的组织学演变之间存在直接比例关系。就p53蛋白而言，其表达在肿瘤性黏膜中升高且常呈透壁性。根据侵袭性细胞分级（ICG）评分，发现Ki67/p53免疫反应性的频率和密度与患者预后不良之间存在密切相关性。相反，高表达p53的恶性细胞似乎不发生凋亡。对头颈部癌前病变和癌中的Ki67抗原和p53蛋白进行检测，可能是管理高危患者的有用标志物。
