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PGI2 enhanced cAMP content in bovine coronary arteries in the presence of isobutylmethylxanthine.

作者信息

Dembinska-Kiec A, Rücker W, Schönhöfer P S

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1979 Aug;308(2):107-10. doi: 10.1007/BF00499051.

DOI:10.1007/BF00499051
PMID:91976
Abstract

Incubation of bovine coronary artery (BCA) rings with isobutylmethylxanthine (IBMX) resulted in a time-dependent increase of cAMP content. This effect was blocked, when the rings were preincubated with indomethacine or 15-hydroperoxy-arachidonic acid for 5 min, indicating that the IBMX-induced increase in cAMP content may depend on endogenous PGI2 formation. PGE2 did not increase the cAMP content in BCA rings. Dipyridamole did not effect cAMP content, when used as a substitute for IBMX. It is suggested that PGI2 stimulates cAMP formation in arterial walls, but that this effect only becomes visible in the presence of a phosphodiesterase inhibitor.

摘要

相似文献

1
PGI2 enhanced cAMP content in bovine coronary arteries in the presence of isobutylmethylxanthine.
Naunyn Schmiedebergs Arch Pharmacol. 1979 Aug;308(2):107-10. doi: 10.1007/BF00499051.
2
Effects of PGI2 and PGI analogues on cAMP levels in cultured endothelial and smooth muscle cells derived from bovine arteries.前列环素（PGI2）及其类似物对源自牛动脉的培养内皮细胞和平滑肌细胞中环磷酸腺苷（cAMP）水平的影响。
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3
Prostacyclin stimulation of dog arterial cyclic AMP levels.
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4
Prostacyclin (PGI2) decreases the cyclic AMP level in coronary arteries.
Naunyn Schmiedebergs Arch Pharmacol. 1979 Jan;306(1):101-3. doi: 10.1007/BF00515602.
5
Mode of action of coronary arterial relaxation by prostacyclin.
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6
Arachidonic acid metabolism in cultured aortic endothelial cells. Effect of cAMP and 3-isobutyl-1-methylxanthine.培养的主动脉内皮细胞中的花生四烯酸代谢。环磷酸腺苷（cAMP）和3-异丁基-1-甲基黄嘌呤的作用。
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7
Prostacyclin increases cAMP in coronary arteries.
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8
Prostacyclin biosynthesis in vascular endothelium is not inhibited by cyclic AMP. Studies with 3-isobutyl-1-methylxanthine and forskolin.血管内皮中前列环素的生物合成不受环磷酸腺苷的抑制。用3-异丁基-1-甲基黄嘌呤和福斯可林进行的研究。
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9
Elevation of cyclic AMP by prostacyclin is accompanied by relaxation of bovine coronary arteries and contraction of rabbit aortic rings.前列环素使环磷酸腺苷升高的同时，牛冠状动脉会舒张，而兔主动脉环会收缩。
Eur J Pharmacol. 1986 Aug 22;128(1-2):25-31. doi: 10.1016/0014-2999(86)90553-4.
10
Effects of dipyridamole in experimental atherosclerosis. Action on PGI2, platelet aggregation and atherosclerotic plaque formation.
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引用本文的文献

1
Responses of human, monkey and dog coronary arteries in vitro to carbocyclic thromboxane A2 and vasodilators.人、猴和犬冠状动脉在体外对碳环血栓素A2和血管扩张剂的反应。
Br J Pharmacol. 1984 Oct;83(2):399-408. doi: 10.1111/j.1476-5381.1984.tb16500.x.
2
Effects of PGI2 and PGI analogues on cAMP levels in cultured endothelial and smooth muscle cells derived from bovine arteries.前列环素（PGI2）及其类似物对源自牛动脉的培养内皮细胞和平滑肌细胞中环磷酸腺苷（cAMP）水平的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1980 Feb;311(1):67-70. doi: 10.1007/BF00500304.
3
Endothelium-derived relaxing factor and atriopeptin II elevate cyclic GMP levels in pig aortic endothelial cells.

本文引用的文献

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Methylene blue but not changes in cyclic GMP inhibits resting and bradykinin-stimulated production of prostacyclin by pig aortic endothelial cells.亚甲蓝而非环鸟苷酸的变化可抑制猪主动脉内皮细胞静息状态下及缓激肽刺激下前列环素的产生。
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Endothelium-mediated coronary dilatation by adenosine does not depend on endothelial adenylate cyclase activation: studies in isolated guinea pig hearts.腺苷介导的内皮依赖性冠状动脉扩张不依赖于内皮腺苷酸环化酶激活：对离体豚鼠心脏的研究。
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A protein binding assay for adenosine 3':5'-cyclic monophosphate.一种用于检测3':5'-环磷酸腺苷的蛋白质结合测定法。
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Role of the platelet in atherogenesis.
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A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation.脂质过氧化物会抑制血管微粒体中的一种酶，该酶能从前列腺素内过氧化物生成一种可防止血小板聚集的物质（前列腺素X）。
Prostaglandins. 1976 Nov;12(5):715-37. doi: 10.1016/0090-6980(76)90048-4.
7
Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides.动脉壁可通过一种由前列腺素内过氧化物生成的物质（前列腺素X）来防止血小板血栓的沉积。
Prostaglandins. 1976 Nov;12(5):685-713. doi: 10.1016/0090-6980(76)90047-2.
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Characteristics of adenylate cyclase activity in pig coronary arteries.猪冠状动脉中腺苷酸环化酶活性的特征
J Cyclic Nucleotide Res. 1978 Jun;4(3):183-99.
9
The generation of prostacyclin by arteries and by the coronary vascular bed is reduced in experimental atherosclerosis in rabbits.在兔实验性动脉粥样硬化中，动脉及冠状血管床生成前列环素的能力降低。
Prostaglandins. 1977;14(6):1025-34. doi: 10.1016/0090-6980(77)90282-9.
10
Differential formation of prostacyclin (PGX or PGI2) by layers of the arterial wall. An explanation for the anti-thrombotic properties of vascular endothelium.动脉壁各层前列环素（PGX或PGI2）的差异生成。对血管内皮抗血栓形成特性的一种解释。
Thromb Res. 1977 Sep;11(3):323-44. doi: 10.1016/0049-3848(77)90185-2.