Dembinska-Kiec A, Rücker W, Schönhöfer P S
Naunyn Schmiedebergs Arch Pharmacol. 1980 Feb;311(1):67-70. doi: 10.1007/BF00500304.
PGI2 increased cAMP levels in cultured endothelial cells derived from bovine aortas in the presence of isobutylmethylxanthine (IBMX). Stable PGI analogues were more effective, while PGE1 was without effect. In cultured smooth muscle cells from bovine aortas, PGI2, pGE1 and the stable PGI analogues dose-dependently increased cAMP levels in the absence and presence of IBMX. The data confirm the stimulatory effect of PGI2 on cAMP content in bovine coronary artery rings and suggest that the effect is mainly due to the stimulatory action of PGI2 on cAMP in smooth muscle cells.
在异丁基甲基黄嘌呤（IBMX）存在的情况下，前列环素（PGI2）可提高源自牛主动脉的培养内皮细胞中的环磷酸腺苷（cAMP）水平。稳定的PGI类似物更有效，而前列腺素E1（PGE1）则无作用。在源自牛主动脉的培养平滑肌细胞中，无论有无IBMX，PGI2、PGE1和稳定的PGI类似物均可剂量依赖性地提高cAMP水平。这些数据证实了PGI2对牛冠状动脉环中cAMP含量的刺激作用，并表明该作用主要归因于PGI2对平滑肌细胞中cAMP的刺激作用。
