Publicover S J, Duncan C J
Naunyn Schmiedebergs Arch Pharmacol. 1979 Aug;308(2):179-82. doi: 10.1007/BF00499062.
Lindane (5 x 10(-5) M) causes a progressive and marked rise in MEPP frequency at the frog neuromuscular junction. Concentrations over a range of 5 x 10(-6) M to 5 x 10(-4) M were tested. The results suggest that it has two actions in promoting this effect. Its major effect is probably to cause an increase in Ca2+-permeability and a rise in Ca2+ entry. Its second, smaller effect, which persists in the absence of extracellular Ca2+, is probably also because of a rise in [Ca2+]i. The ways in which these effects might be produced and the significance of these findings for explaining the known pharmacological actions of lindane are discussed.
林丹（5×10⁻⁵ M）可使青蛙神经肌肉接头处的微小终板电位（MEPP）频率逐渐显著升高。测试了5×10⁻⁶ M至5×10⁻⁴ M范围内的浓度。结果表明，它在促进这种效应方面有两种作用。其主要作用可能是导致Ca²⁺通透性增加和Ca²⁺内流增加。其第二种较小的作用，在没有细胞外Ca²⁺的情况下仍然存在，可能也是由于细胞内Ca²⁺浓度（[Ca²⁺]i）升高。讨论了这些效应可能产生的方式以及这些发现对于解释林丹已知药理作用的意义。
