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聚阳离子配体阳离子化铁蛋白对量子递质释放的抑制作用。

Inhibition of quantal transmitter release by the polycationic ligand cationized ferritin.

作者信息

Publicover S J

出版信息

Exp Brain Res. 1985;59(3):629-32. doi: 10.1007/BF00261355.

DOI:10.1007/BF00261355
PMID:2863166
Abstract

Cationized ferritin (200 micrograms ml-1) causes a reduction in both spontaneous and evoked transmitter release at the frog neuromuscular junction. The reduction in EPP amplitude probably reflects reduced Ca2+ -influx since full recovery can be achieved by elevation of [Ca2+]o. The effect on MEPP frequency is independent of [Ca2+]o and may well reflect a direct effect on exocytosis.

摘要

阳离子铁蛋白（200微克/毫升）可使青蛙神经肌肉接头处的自发递质释放和诱发递质释放均减少。终板电位（EPP）幅度的降低可能反映了Ca2+内流的减少，因为通过提高细胞外Ca2+浓度（[Ca2+]o）可实现完全恢复。对微小终板电位（MEPP）频率的影响与[Ca2+]o无关，很可能反映了对胞吐作用的直接影响。

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Exp Brain Res. 1985;59(3):629-32. doi: 10.1007/BF00261355.
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本文引用的文献

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THE DEPENDENCE OF CONTRACTION AND RELAXATION OF MUSCLE FIBRES FROM THE CRAB MAIA SQUINADO ON THE INTERNAL CONCENTRATION OF FREE CALCIUM IONS.螃蟹（黄道蟹）肌纤维收缩与舒张对游离钙离子胞内浓度的依赖性
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3
Binding of cationized and native ferritin to cellular structures of the electric organ of Torpedo marmorata.
阳离子化铁蛋白和天然铁蛋白与电鳐电器官细胞结构的结合。
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4
The chromaffin granule as a model for membrane fusion: implications for exocytosis.嗜铬粒蛋白作为膜融合模型：对胞吐作用的启示。
J Auton Nerv Syst. 1983 Jan;7(1):19-33. doi: 10.1016/0165-1838(83)90066-8.
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The calcium dependence of spontaneous and evoked quantal release at the frog neuromuscular junction.青蛙神经肌肉接头处自发和诱发量子释放的钙依赖性。
J Physiol. 1983 Apr;337:735-51. doi: 10.1113/jphysiol.1983.sp014652.
6
Inhibition of spontaneous transmitter release by the membrane ligand cationized ferritin.膜配体阳离子铁蛋白对自发递质释放的抑制作用。
Naunyn Schmiedebergs Arch Pharmacol. 1982 Feb;318(3):246-8. doi: 10.1007/BF00500487.
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Mechanisms of cell fusion.细胞融合的机制。
Nature. 1975 Jan 17;253(5488):194-5. doi: 10.1038/253194a0.
8
Inhibitory effects of cholinergic agents on the release of transmitter at the frog neuromuscular junction.胆碱能药物对蛙神经肌肉接头处递质释放的抑制作用。
J Physiol. 1979 Sep;294:91-103. doi: 10.1113/jphysiol.1979.sp012917.