Sciscione A C, Bessos H, Callan N, Blakemore K, Kickler T
Department of Gynaecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Br J Obstet Gynaecol. 1997 Jun;104(6):743-5. doi: 10.1111/j.1471-0528.1997.tb11990.x.
Glycocalicin has been found to be a marker of increased platelet turnover, while interleukin-6 may be increased in response to thrombocytopenia. We used these markers to study the pathophysiology of thrombocytopenia in newborn infants. Cord blood platelet counts were obtained from 499 infants. Thrombocytopenic infants (< 100,000/mm3) and a control group had ELISA assays for interleukin-6 and glycocalicin performed. The mean levels of glycocalicin and interleukin-6 were elevated in cord blood of thrombocytopaenic infants. Infants with intrauterine growth restriction and thrombocytopaenia had no detectable glycocalicin in their plasma, despite elevated levels of interleukin-6. This probably reflects impaired thrombopoiesis in these infants.
已发现糖钙蛋白是血小板更新增加的标志物，而白细胞介素-6可能因血小板减少而升高。我们使用这些标志物来研究新生儿血小板减少的病理生理学。从499名婴儿获取脐带血血小板计数。对血小板减少的婴儿（<100,000/mm³）和对照组进行白细胞介素-6和糖钙蛋白的酶联免疫吸附测定。血小板减少婴儿脐带血中糖钙蛋白和白细胞介素-6的平均水平升高。患有宫内生长受限和血小板减少的婴儿，尽管白细胞介素-6水平升高，但其血浆中未检测到糖钙蛋白。这可能反映了这些婴儿的血小板生成受损。
